Journal
NEUROSCIENCE LETTERS
Volume 453, Issue 1, Pages 58-61Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.01.067
Keywords
Ghrelin; Neuronal death; Neuroprotective effect; Seizure; Hippocampus; Pilocarpine
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Funding
- National Natural Science Foundation of China [30870838]
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Ghrelin, a 28-amino-acid peptide, is mainly secreted by the stomach. Evidence has shown ghrelin to have neuroprotective effects. However, whether ghrelin protects hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. We used Nissl staining to show that ghrelin attenuated the neuronal loss caused by pilocarpine-induced seizures in the hippocampus. Ghrelin exerted the protective action through regulating the phosphatidylinositol-3-kinase and Akt pathway. Moreover, ghrelin treatment reversed the decreased ratio of Bcl-2 to Bax induced by seizures while inhibiting the activated caspase-3. Ghrelin can inhibit hippocampal neuronal damage caused by pilocarpine-induced seizures, which might have therapeutic value in seizures. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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