Journal
NEUROSCIENCE LETTERS
Volume 466, Issue 2, Pages 81-88Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.08.032
Keywords
Transcriptome; Non-coding RNA; Neuronal stress; Synaptic plasticity; Alzheimer's disease
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Funding
- NIA NIH HHS [R21 AG029290-02, R21 AG029290] Funding Source: Medline
- NIMH NIH HHS [R01 MH084880] Funding Source: Medline
- NINDS NIH HHS [R01 NS063974-01A1, R01 NS063974] Funding Source: Medline
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Non-protein-coding RNAs (ncRNAs) play critical roles on many levels of cellular information processing and pervasive expression of ncRNAs in the nervous system could help explain brain complexity. NcRNAs are enriched in the central nervous system and are associated with specific neuroanatomical regions. Additionally, several recent publications have revealed an important role for deregulation of ncRNAs in various human neuropathologies, such as Alzheimer's disease, Parkinson's disease and Fragile X mental retardation. Herein, we summarize reports on functional ncRNA molecules involved in cellular stress response, particularly related to Alzheimer's disease. We conclude that ncRNAs have a prominent role in maintaining precise physiological levels of gene products directly implicated in Alzheimer's disease pathology. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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