Journal
NEUROSCIENCE LETTERS
Volume 459, Issue 2, Pages 62-65Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.05.007
Keywords
Intracerebral hemorrhage; Protease-activated receptor-1; Thrombin
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Funding
- Construction Project of Medical Key Subject in Zhejiang Province of China [2007.7-2010.7]
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Thrombin plays an important role in brain injuries associated with intracerebral hemorrhage (ICH). The protease-activated receptor (PAR)-1 is responsible for the vast majority of the thrombin's cellular activation functions. We tested the hypothesis that thrombin-incluced brain damage after ICH, at least in part, is mediated by PAR-1. We report that there are significant differences between PAR-1 positive cell number and PAR-1 mRNA absorbance ratio between ICH model group (at 6 h, 24 h, 3 d, 7 d and 14 d) and normal group (P<0.05). These results suggest that the long-time course of PAR-1 expression may be partly involved in the mechanism of thrombin-induced brain damage after ICH. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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