Journal
NEUROSCIENCE LETTERS
Volume 450, Issue 1, Pages 56-59Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.10.091
Keywords
Mild cognitive impairment; Alzheimer's disease; Soluble CD40; CD40 ligand; Beta-amyloid; CSF
Categories
Funding
- Swedish Alzheimer Foundation, Lund, Sweden
- the Segerfalk Foundation
- Stiftelsen Gamla Tjanarinnor
- the Swedish Research Council
- Skane County Council's Research and Development Foundation
- The Swedish Foundations of the National Board of Health and Welfare
- the Goteborg Medical Society: the Ake Wiberg Foundation
- the Sahlgrenska University Hospital
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CD40 is a member of the tumor necrosis factor receptor super-family and has been Suggested to play a role in the metabolism of beta-amyloid (A beta) in Alzheimer's disease (AD). However, the role of CD40-signalling in incipient AD has not yet been studied. We investigated the plasma levels of soluble CD40 (sCD40) and the soluble CD40 ligand (sCD40L) at baseline in 136 subjects with mild cognitive impairment (MCI) and 30 age-matched controls. Sixty of the 136 MCI cases converted to AD (MCI-AD) during a clinical follow-up period of 4-7 years. The baseline levels of sCD40, but not sCD40L, were elevated in MCI-AD cases when compared to age-matched controls (Mann-Whitney U-test, p=0.02). However, MCI patients who were cognitively stable or developed vascular dementia during follow-up did not have significantly increased levels of sCD40 or sCD40L when compared to controls. The levels of sCD40 correlated to decreased baseline performance on mini-mental state examination (MMSE) in both controls (r(s)= -0.37, p<0.05) and MCI-AD cases (r(s)=-0.29, p<0.05). Finally, the plasma levels of sCD40 correlated with the levels Of Soluble amyloid precursor protein-alpha (sAPP-alpha) (r(s)=0.28, p<0.01) and sAPP-beta (r(s)=0.23, p<0.05) in cerebrospinal fluid. In conclusion, CD40-signalling might play a role in the pathogenesis of early AD. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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