Journal
NEUROSCIENCE LETTERS
Volume 452, Issue 1, Pages 33-36Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.01.032
Keywords
Cyclooxygenase; Dura; Headache; Migraine; Trigeminal; NSAID; Inflammation
Categories
Funding
- NIH [NS046502, NS032534, NS051484]
- National Headache Foundation
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Primary headaches such as migraine can be aborted by systemic administration of non-steroidal anti-inflammatory drugs (NSAIDs), potentially through the non-selective inhibition of cyclooxygenase (COX) activity in the intracranial meninges. In this study we have used single and double labeling immuno-histochemistry to examine the distribution of the COX-1 and COX-2 isoforms in the intracranial dura mater of the rat and identify cell types that express them. COX-1 immunoreactivity was found in medium and small dural blood vessels and was co-expressed with the endothelial cell markers vimentin and the endothelial isoform of nitric oxide synthase (ecNOS). COX-1 was also found to be present in most dural mast cells. COX-2 was mainly expressed in ED2-positive resident dural macrophages. Constitutive COX-2 expression was also found in some axonal profiles, many of which were co-labeled with the nociceptor peptide marker CGRP. The findings Suggest that NSAIDs may abort headache, at least in part, by inhibiting either neuronal or non-neuronal COX activity in the dura mater. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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