Journal
NEUROSCIENCE LETTERS
Volume 452, Issue 1, Pages 79-83Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.01.022
Keywords
Osmolality; Action potential; TRPV4; Intracellular signaling pathway; Nociception
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Funding
- National Institute of General Medical Sciences [GM-63577]
- USA and Philip Morris International and National Natural Science Foundation of China [30571537]
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The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment. Transient Receptor Potential Vanilloid 4 receptor (TRPV4) activator increased the number of APs, but only hypotonic-response was markedly blocked in TRPV4(-/-) mice. Additionally, inhibition of PKC attenuated hypotonicity-induced increase, whereas antagonism of PKA attenuated hypertonicity-response. We conclude that anisotonicity increases excitability of nociceptors, which might be involved in anisotonicity-induced nociception. The increase of APs by hypo- and hypertonicity is mediated through different receptor and intracellular signaling pathways. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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