Journal
NEUROSCIENCE LETTERS
Volume 440, Issue 2, Pages 113-118Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.05.031
Keywords
herpes; virus; dendritic filopodia; retrograde F-actin; surfing
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Funding
- NIAID NIH HHS [R01 AI057860-04, AI057860, R01 AI057860] Funding Source: Medline
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Herpes simplex virus type-1 (HSV-1) is a neurotropic virus with significant potential as a viral vector for central nervous system (CNS) gene therapy. This study provides visual evidence that recombinant green fluorescent protein (GFP)-expressing HSV-1 travel down dendrites in differentiated P19 neuronal-like cells to efficiently reach the soma. The virus also promotes cytoskeletal rearrangements which facilitate viral spread in vitro, including often dramatic increases in dendritic filopodia. Viral movements, cell infection and filopodia induction were each reduced with the actin polymerization inhibitor cytochalasin D, suggesting the involvement of the actin cortex in these processes. The observation of neural cytoskeletal reorganization in response to HSV-I may shed light on the mechanisms by which acute viral infection associated with herpes encephalitis produces cognitive deficits in patients. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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