Journal
NEUROSCIENCE LETTERS
Volume 430, Issue 1, Pages 60-63Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.10.010
Keywords
disrupted in schizophrenia 1; poor concentration; schizophrenia; single nucleotide polymorphism
Categories
Ask authors/readers for more resources
To further clarify schizophrenia (SCZ), disrupted in schizophrenia 1 (DISC1) is a promising candidate gene expressed predominantly within the hippocampus. Several lines of evidence suggest that DISC1 may be involved in susceptibility to SCZ. In this study, we investigated whether genetic polymorphisms in the coding region of DISCI were associated with several SCZ clinical phenotypes in a Korean population. To examine any association between DISCI and SCZ, we genotyped three clinical single nucleotide polymorphisms (SNPs) (rs3738401, R264Q; rs3738402, L465L; rs821616, S704C) in the coding region of the DISC1 gene using the Illumina Sentrix Array Matrix chip and direct sequencing in 303 patients with SCZ and 300 healthy controls. Our case-control analysis showed that none of these SNPs was associated with SCZ. In further endophenotype stratification, however, we found a significant association between rs821616 and the poor concentration subgroup of SCZ, determined using the Operational Criteria Checklist (codominant model, p=0.015). Our results suggest that DISCI may be a susceptibility gene for poor concentration among Korean patients with SCZ. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available