Journal
NEUROSCIENCE LETTERS
Volume 433, Issue 3, Pages 235-240Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.01.013
Keywords
alpha1 and alpha2-adrenoceptors; prazosin; idazoxan; avoidance; learning; locomotion; memory
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Studies on the neurotransmitter substrate of locomotion and place navigation occupy a central position in behavioral neuroscience. Active allothetic place avoidance (AAPA) is a task, in which animals are trained to avoid a room frame defined stable sector on a continuously rotating arena. The aim of the present study was to test the effect of the blockage of alpha] - and alpha2-adrenoceptors, using specific antagonists prazosin and idazoxan, on the locomotor activity and spatial behavior in the AAPA task. Both prazosin and idazoxan at the highest doses (4 and 6 mg/kg, respectively) were found to decrease the locomotor activity in the AAPA and they also impaired navigational performance. The results suggest that antagonizing alpha-adrenoceptors with systemically administered drugs affects locomotor activity together with avoidance behavior and does not cause a purely cognitive deficit in the AAPA task. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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