Journal
NEUROSCIENCE LETTERS
Volume 439, Issue 2, Pages 216-219Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.05.018
Keywords
ROS; PBN; analgesia; free radical; sensitization; hyperalgesia
Categories
Funding
- NIA NIH HHS [AG13945] Funding Source: Medline
- NINDS NIH HHS [NS 11255, NS 31680, NS 10161] Funding Source: Medline
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To examine a possible involvement of reactive oxygen species (ROS) in visceral pain the levels of ROS, in the colon and the effect of a ROS scavenger phenyl N-t-butylnitrone (PBN) on pain were examined in zymosan-induced colitis rats. Zymosan was instilled into the colon of adult rats. The electromyograms (EMGs) of abdominal muscle contractions in response to colorectal distension (CRD) were recorded as an indicator of visceral pain. After zymosan treatment, the rats showed enhanced EMG and elevated levels of H2O2 in the colon. PBN treatment (intraperitoneal, intrathecal or intracolonic) significantly reduced the enhanced EMGs induced by zymosan. The results suggest that elevated ROS in the spinal cord and the colon are involved in visceral pain. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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