Journal
NEUROSCIENCE LETTERS
Volume 430, Issue 3, Pages 224-229Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.11.002
Keywords
cerebrospinal fluid histamine; modafinil; amphetamine; thioperamide; sleep deprivation; food deprivation
Categories
Funding
- NIMH NIH HHS [R03 MH079258, R01 MH072525-02, R03 MH 079258, R01 MH072525-01A2, R01 MH 072525, R01 MH072525, R03 MH079258-01] Funding Source: Medline
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Reduced cerebrospinal fluid (CSF) histamine levels were found in human hypersomnia. To evaluate the functional significance of changes in CSF histamine levels. we measured the levels in rats across 24 h, after the administration of wake-promoting compounds modafinil, amphetamine, and thioperamide, and after sleep deprivation and food deprivation. Thioperamide significantly increased CSF histamine levels with little effects on locomotor activation. Both modafinil and amphetamine markedly increased the locomotor activity, but had no effects on histamine. The levels are high during active period and are markedly elevated by sleep deprivation, but not by food deprivation. Our study suggests that CSF histamine levels in rats reflect the central histamine neurotransmission and vigilance state changes, providing deeper insight into the human data. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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