Journal
NEUROSCIENCE LETTERS
Volume 430, Issue 1, Pages 34-37Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.10.011
Keywords
nicotinic acetylcholine receptors; smoking; positron emission tomography; 2-[F-18]F-A-85380
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The role of the alpha 4 beta 2* nicotinic acetylcholine receptors (nAChR) in tobacco addiction in humans is largely unresolved. We visualized brain alpha 4 beta 2* nicotinic acetylcholine receptors of smokers and non-smokers with positron emission tomography using 2-[F-18]fluoro-3-(2(S)azetidinylmethoxy)pyridine, commonly known as 2-[F-18]F-A-85380. The total brain distribution volume of 2-[F-18]F-A-85380 was significantly increased in smokers. Statistical parametric mapping revealed that the most prominent regional differences of distribution volumes (DV) were found in cerebellum and brainstem with an increased uptake in smokers. The up-regulation of alpha 4 beta 2* nAChR upon chronic nicotine exposure via tobacco smoking incorporates subcortical brain regions which may play an important role in nicotine addiction. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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