Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 97, Issue -, Pages 10-33Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2018.09.012
Keywords
Social withdrawal; Neurobiology; Social brain; Social dysfunction; Social impairments; Social cognition; Social functioning; Schizophrenia; Alzheimer's disease; Major depression disorder
Categories
Funding
- Innovative Medicines Initiative 2 Joint Undertaking [115916]
- European Union's Horizon 2020 research and innovation programme
- European Federation of Pharmaceutical Industries and Associations (EFPIA)
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The human social brain is complex. Current knowledge fails to define the neurobiological processes underlying social behaviour involving the (patho-) physiological mechanisms that link system-level phenomena to the multiple hierarchies of brain function. Unfortunately, such a high complexity may also be associated with a high susceptibility to several pathogenic interventions. Consistently, social deficits sometimes represent the first signs of a number of neuropsychiatric disorders including schizophrenia (SCZ), Alzheimer's disease (AD) and major depressive disorder (MDD) which leads to a progressive social dysfunction. In the present review we summarize present knowledge linking neurobiological substrates sustaining social functioning, social dysfunction and social withdrawal in major psychiatric disorders. Interestingly, AD, SCZ, and MDD affect the social brain in similar ways. Thus, social dysfunction and its most evident clinical expression (i.e., social withdrawal) may represent an innovative transdiagnostic domain, with the potential of being an independent entity in terms of biological roots, with the perspective of targeted interventions.
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