Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 46, Issue -, Pages 161-174Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2014.02.015
Keywords
Intellectual disability; Autism spectrum disorders; Synaptic plasticity; Neurodevelopmental disorder; Molecular pathways
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Funding
- National Institute of Child Health and Human Development [R01-HD039331]
- National Institute of Neurological Disorders and Stroke [R01-NS073854]
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Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common developmental disorders present in humans. Combined, they affect between 3 and 5% of the population. Additionally, they can be found together in the same individual thereby complicating treatment. The causative factors (genes, epigenetic and environmental) are quite varied and likely interact so as to further complicate the assessment of an individual patient. Nonetheless, much valuable information has been gained by identifying candidate genes for ID or ASD. Understanding the etiology of either ID or ASD is of utmost importance for families. It allows a determination of the risk of recurrence, the possibility of other comorbidity medical problems, the molecular and cellular nature of the pathobiology and hopefully potential therapeutic approaches. (C) 2014 Elsevier Ltd. All rights reserved.
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