Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 45, Issue -, Pages 9-18Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2014.04.011
Keywords
Lateral prefrontal cortex; Decision making; reward; fMRI; Cognitive control; Model-based learning; Value; Ventromedial prefrontal cortex; Rostro-caudal organization; Rules
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Funding
- Natural Sciences and Engineering Council of Canada (NSERC) [05-5918]
- Institute of Neurosciences, Mental Health and Addiction (INMHA) [112361]
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Tremendous progress has been made in discerning the neurocognitive basis of value-based decision making and learning. Although the majority of studies to date have employed simple task paradigms, recent work has started to examine more complex aspects of value processing including: the value of engaging rule-based cognitive control; the integration of multiple pieces of information (e.g., reward magnitude and delay) to discern the best course of action; pursuing future rewards; valuation of abstract concepts (e.g., fairness); and comparing the value of executed versus imagined alternative actions. We provide a comprehensive review of functional neuroimaging, electrophysiological, and lesion evidence suggesting that the lateral prefrontal cortex (LPFC) plays a critical role in these complex aspects of value processing. In particular, we focus on the specific information that the LPFC represents, and argue that it includes both cognitive and value-based information. We also discuss how the role of the LPFC is distinct from other value-related regions. Finally, we articulate a framework for understanding the contribution of subregions along the rostro-caudal axis of the LPFC, and thereby bridge the cognitive control and decision making literatures. (C) 2014 Elsevier Ltd. All rights reserved.
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