Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 37, Issue 9, Pages 1946-1954Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2013.02.010
Keywords
Drug addiction; Cocaine; Ventral striatum; Dorsal striatum; Prefrontal cortex
Categories
Funding
- MRC
- Wellcome Trust
- Medical Research Council [G1000183B, G1002231, G0001354, G0001354B] Funding Source: researchfish
- MRC [G1002231] Funding Source: UKRI
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We revisit our hypothesis that drug addiction can be viewed as the endpoint of a series of transitions from initial voluntarily drug use to habitual, and ultimately compulsive drug use. We especially focus on the transitions in striatal control over drug seeking behaviour that underlie these transitions since functional heterogeneity of the striatum was a key area of Ann Kelley's research interests and one in which she made enormous contributions. We also discuss the hypothesis in light of recent data that the emergence of a compulsive drug seeking habit both reflects a shift to dorsal striatal control over behaviour and impaired prefontal cortical inhibitory control mechanisms. We further discuss aspects of the vulnerability to compulsive drug use and in particular the impact of impulsivity. In writing this review we acknowledge the untimely death of an outstanding scientist and a dear personal friend. (C) 2013 Elsevier Ltd. All rights reserved.
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