Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 37, Issue 10, Pages 2666-2675Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2013.09.002
Keywords
Dementia; Alzheimer's disease; Memory; Neuroanatomy; Fornix; Entorhinal cortex; Hippocampus; Nucleus basalis of Meynert; Limbic system; Deep brain stimulation; Papez circuit
Categories
Funding
- Internationale Stichting Alzheimer Onderzoek (ISAO)
Ask authors/readers for more resources
Memory loss is the key symptom of dementia-related disorders, including the prevalent Alzheimer's disease (AD). To date, pharmacological treatments for AD have limited and short-lasting effects. Therefore, researchers are investigating novel therapies such as deep brain stimulation (DBS) to treat memory impairment and to reduce or stop the progression of it. Clinical and preclinical studies have been performed and stimulations of the fornix, entorhinal cortex and nucleus basalis of Meynert have been carried out. The results of these studies suggest that DBS has the potential to enhance memory functions in patients and animal models. The mechanisms underlying memory enhancement may include the release of specific neurotransmitters and neuroplasticity. Some authors suggest that DBS might even be disease-modifying. Nevertheless, it is still premature to conclude that DBS can be used in the treatment of AD, and the field will wait for the results of ongoing clinical trials. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available