Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 36, Issue 9, Pages 2044-2055Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2012.07.005
Keywords
GABA; Autism spectrum disorders; GABA(A) receptor; Inhibitory interneurons; Autism; Fragile X Syndrome; Rett Syndrome; Foetal Anticonvulsant Syndrome
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Funding
- Medical Research Council [G1002226, G0400061] Funding Source: Medline
- Wellcome Trust [091300] Funding Source: Medline
- Department of Health [RP-PG-0606-1045] Funding Source: Medline
- Medical Research Council [G0400061, G1002226] Funding Source: researchfish
- National Institute for Health Research [RP-PG-0606-1045] Funding Source: researchfish
- MRC [G1002226, G0400061] Funding Source: UKRI
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Autism spectrum disorders (ASDs) are neurodevelopmental syndromes characterised by repetitive behaviours and restricted interests, impairments in social behaviour and relations, and in language and communication. These symptoms are also observed in a number of developmental disorders of known origin, including Fragile X Syndrome, Rett Syndrome, and Foetal Anticonvulsant Syndrome. While these conditions have diverse etiologies, and poorly understood pathologies, emerging evidence suggests that they may all be linked to dysfunction in particular aspects of GABAergic inhibitory signalling in the brain. We review evidence from genetics, molecular neurobiology and systems neuroscience relating to the role of GABA in these conditions. We conclude by discussing how these deficits may relate to the specific symptoms observed. (C) 2012 Elsevier Ltd. All rights reserved.
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