Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 36, Issue 6, Pages 1510-1531Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2012.03.007
Keywords
Children; TBI; Concussion; Adolescents; Brain; Cortex; Cognitive; Hypothalamus; Autonomic; Brain imaging; fMRI
Categories
Funding
- NINDS [K24NS064050]
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Concussion (mild traumatic brain injury (mTBI)) is a significant pediatric public health concern. Despite increased awareness, a comprehensive understanding of the acute and chronic effects of concussion on central nervous system structure and function remains incomplete. Here we review the definition, epidemiology, and sequelae of concussion within the developing brain, during childhood and adolescence, with current data derived from studies of pathophysiology and neuroimaging. These findings may contribute to a better understanding of the neurological consequences of traumatic brain injuries, which in turn, may lead to the development of brain biomarkers to improve identification, management and prognosis of pediatric patients suffering from concussion. (C) 2012 Elsevier Ltd. All rights reserved.
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