Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 36, Issue 5, Pages 1357-1375Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2012.02.011
Keywords
Amyloid; Alzheimer's disease; Open-field; Spontaneous alternation; Elevated plus-maze; Emergence test; GABA; Aggression
Categories
Funding
- National Institutes of Health [AG030399]
- Alzheimer's Association of America
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The discovery of gene mutations responsible for autosomal dominant Alzheimer's disease has enabled researchers to reproduce in transgenic mice several hallmarks of this disorder, notably A beta accumulation, though in most cases without neurofibrillary tangles. Mice expressing mutated and wild-type APP as well as C-terminal fragments of APP exhibit variations in exploratory activity reminiscent of behavioural and psychological symptoms of Alzheimer dementia (BPSD). In particular, open-field, spontaneous alternation, and elevated plus-maze tasks as well as aggression are modified in several APP transgenic mice relative to non-transgenic controls. However, depending on the precise murine models, changes in open-field and elevated plus-maze exploration occur in either direction, either increased or decreased relative to controls. It remains to be determined which neurotransmitter changes are responsible for this variability, in particular with respect to GABA, 5HT, and dopamine. (C) 2012 Elsevier Ltd. All rights reserved.
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