Journal
NEUROSCIENCE
Volume 274, Issue -, Pages 24-32Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2014.05.003
Keywords
aromatase; estrogen; sexual dimorphism; synaptic plasticity
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Funding
- Deutsche Forschungsgemeinschaft - Germany
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Increasing evidence points to an essential role played by neuron-derived neurosteroids, such as estrogen, on synaptic connectivity in the hippocampus. Inhibition of local estradiol synthesis results in synapse loss specifically in females, but not in males. Synapse loss in females, after inhibition of estradiol synthesis in hippocampal neurons, appears to result from impairment of long-term potentiation (LTP) and dephosphorylation of cofilin, and thereby the destabilization of postsynaptic dendritic spines. Such clear-cut effects were not seen in males. Cognitive deficits after inhibition of aromatase, the final enzyme of estrogen synthesis, have been seen in women, but not in men. Altogether, the data demonstrate distinct differences between genders in neurosteroid-induced synaptic stability. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
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