Journal
NEUROSCIENCE
Volume 264, Issue -, Pages 25-38Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2013.12.009
Keywords
epigenetics; long non-coding RNAs; enhancer RNAs
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Funding
- National Institute of Mental Health Institutional Training Grant [T32-MH76690]
- Whitehall foundation
- Welch foundation
- Klingenstein Fund
- NIH-NINDS [1R01NS085418]
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Long non-coding RNAs (lncRNAs) have been increasingly appreciated as an integral component of gene regulatory networks. Genome-wide features of their origin and expression patterns ascribed a prominent role for lncRNAs to the regulation of protein-coding genes, and also suggest a potential link to many human diseases. Recent studies have begun to unravel the intricate regulatory mechanism of lncRNAs occurring at multiple levels. The brain is one of the richest sources of lncRNAs, many of which have already shown a close relationship with genes or genetic loci implicated in a wide range of neurological disorders. This review describes recently emerging mechanistic principles of lncRNA functions to provide neuroscientists with molecular insights that will help future research on lncRNAs in the brain. This article is part of a Special Issue entitled: Epigenetics in Brain Function (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
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