Journal
NEUROSCIENCE
Volume 239, Issue -, Pages 157-172Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2012.09.073
Keywords
BDNF; glucocorticoids; TrkB; GR; MR; HPA-axis
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Funding
- Long-range Research Initiative (LRI) by Japan Chemical Industry Association (JCIA)
- Takeda Science Foundation
- Ichiro Kanehara Foundation
- Hokuto Foundation for Bioscience
- Core Research for Evolutional Science and Technology Program (CREST) Japan Science and Technology Agency (JST)
- Health and Labor Sciences Research Grants [H21-kokoro-002]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [20390318, 24300139]
- Grants-in-Aid for Scientific Research [20390318] Funding Source: KAKEN
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Brain-derived neurotrophic factor (BDNF) has multiple roles in the central nervous system (CNS), including maintaining cell survival and regulation of synaptic function. In CNS neurons, BDNF triggers activation of phospholipase C gamma (PLC gamma), mitogen-activated protein/extracellular signal-regulated kinase (MAPK/ERK), and phosphoinositide 3-kinase (PI3K)/Akt pathways, influencing neuronal cells beneficially through these intracellular signaling cascades. There is evidence to suggest that decreased BDNF expression or function is related to the pathophysiology of brain diseases including psychiatric disorders. Additionally, glucocorticoids, which are critical stress hormones, also influence neuronal function in the CNS, and are putatively involved in the onset of depression when levels are abnormally high. In animal models of depression, changes in glucocorticoid levels, expression of glucocorticoid receptor (GR), and alterations in BDNF signaling are observed. Interestingly, several studies using in vivo and in vitro systems suggest that glucocorticoids interact with BDNF to ultimately affect CNS function. In the present review, we provide an overview of recent evidence concerning the interaction between BDNF and glucocorticoids. This article is part of a Special Issue entitled: Steroid hormone actions in the CNS: the role of BDNF. (C) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
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