Journal
NEUROSCIENCE
Volume 253, Issue -, Pages 398-405Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2013.09.001
Keywords
reconsolidation; updating; retrieval; object recognition memory; perirhinal cortex; rats
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Funding
- CONACYT-Mexico [155242]
- DGAPA-UNAM
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Reconsolidation refers to the destabilization/restabilization process upon memory reactivation. However, the parameters needed to induce reconsolidation remain unclear. Here we evaluated the capacity of memory retrieval to induce reconsolidation of object recognition memory in rats. To assess whether retrieval is indispensable to trigger reconsolidation, we injected muscimol in the perirhinal cortex to block retrieval, and anisomycin (ani) to impede reconsolidation. We observed that ani impaired reconsolidation in the absence of retrieval. Therefore, stored memory underwent reconsolidation even though it was not recalled. These results indicate that retrieval and reconsolidation of object recognition memory are independent processes. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
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