Journal
NEUROSCIENCE
Volume 244, Issue -, Pages 42-48Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2013.04.005
Keywords
memory; reconsolidation; nimodipine; rat; updating; extinction
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Funding
- CAPES (MEC) - PNPD
- CNPq (MCT)
- PROPESQ (UFRGS)
- International Foundation for Science (IFS, Stockholm)
- FINEP (Rede Instituto Brasileiro de Neurociencias - IBN-Net) in Brazil [01.06.0842-00]
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Although much has been learned regarding the molecular and cellular mechanisms of memory reconsolidation, its actual biological function remains unclear. In this work we investigate the possibility that three different mnemonic processes - updating, precision-keeping and trace strengthening - are mediated by reconsolidation in contextual fear conditioning. Reconsolidation involves the activation of calcium channels for the destabilization during the reactivation. Our results show that when memory is reactivated in a situation that does not match the original information, content is modified, i.e., updated. However, when the contextual condition matches the original one, memory reactivation contributes either to its strengthening or to the maintenance of its precision content over time. Since the L-type voltage-gated calcium channel antagonist nimodipine blocked these effects, we suggest that reconsolidation is the mechanism supporting these processes. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
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