Journal
NEUROSCIENCE
Volume 171, Issue 4, Pages 1180-1186Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2010.10.005
Keywords
GHS-R1A; dopamine; appetite; reward seeking; CPP; palatable food
Categories
Funding
- Konrad and Helgfrid Johanssons Fond
- Fredrik and Ingrid Thurings Stiflelse
- EU [FP7 HEALTH 2009-241592, FP7 KBBE-2009-3 245009]
- Swedish Medical Research Council [K2007 54X 20328-013]
- ALF Goteborg [SU7601]
- Swedish Foundation for Strategic Research to Sahlgrenska Center for Cardiovascular and Metabolic Research [A305-188]
- National Science Foundation of Hungary [OTKA K69127, T73002]
Ask authors/readers for more resources
Here we sought to determine whether ghrelin s central effects on food intake can be interrupted by nicotine acetylcholine receptor (nAChR) blockade Ghrelin regulates mesolimbic dopamine neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens partly via cholinergic VTA afferents originating in the laterodorsal tegmental area (LDTg) Given that these cholinergic projections to the VTA have been implicated in natural as well as drug-induced reinforcement, we sought to investigate the role of cholinergic signaling in ghrelin induced food intake as well as fasting-induced food intake, for which endogenous ghrelin has been implicated We found that i p treatment with the non selective centrally active nAChR antagonist, mecamylamine decreased fasting induced food intake in both mice and rats Moreover, central administration of mecamylamine decreased fasting-induced food intake in rats I c v ghrelin induced food intake was suppressed by mecamylamine i p but not by hexamethonium i p, a peripheral nAChR antagonist Furthermore, mecamylamine i p blocked food intake following ghrelin injection into the VTA Expression of the ghrelin receptor, the growth hormone secretagogue receptor 1A, was found to co-localize with choline acetyltransferase, a marker of cholinergic neurons, in the LDTg Finally, mecamylamine treatment i p decreased the ability of palatable food to condition a place preference These data suggest that ghrelin induced food intake is partly mediated via nAChRs and that nicotinic blockade decreases the rewarding properties of food (C) 2010 IBRO Published by Elsevier Ltd All rights reserved
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available