Journal
NEUROSCIENCE
Volume 158, Issue 3, Pages 972-982Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2008.08.028
Keywords
microvessels; microvessel-neuron distribution; astrocytes; endothelial cells; integrins; dystroglycan
Categories
Funding
- NINDS NIH HHS [R37 NS038710, R01 NS026945-15, R01 NS038710, R37 NS038710-09, R01 NS038710-04, R01 NS026945, R01 NS053716] Funding Source: Medline
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Responses to focal cerebral ischemia by neurons and adjacent microvessels are rapid, simultaneous, and topographically related. Recent observations indicate the simultaneous appearance of proteases by components of nearby microvessels that are also expressed by neurons in the ischemic territory, implying that the events could be coordinated. The structural relationship of neurons to their microvascular supply, the direct functional participation of glial cells, and the observation of a highly ordered microvessel-neuron response to ischemia suggest that these elements are arranged in and behave in a unitary fashion, the neurovascular unit. Their roles as a unit in the stimulation of cellular inflammation and the generation of inflammatory mediators during focal cerebral ischemia have not been explored yet. However, components of the neurovascular unit both generate and respond to these influences under the conditions of ischemia. Here we briefly explore the potential inter-relationships of the components of the neurovascular unit with respect to their potential roles in ischemia-induced inflammatory responses. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
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