Journal
NEUROSCIENCE
Volume 158, Issue 1, Pages 45-54Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2007.12.046
Keywords
glutamate receptor; stargazin; trafficking; auxiliary subunit; plasticity; electrophysiology
Categories
Funding
- Deutsche Forschungsgemeinschaft [DFG: HO 1118/11-1]
Ask authors/readers for more resources
The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous trafficking and scaffolding proteins. Participating in the delivery and synaptic localization of AMPA receptors is a recently discovered protein family named transmembrane AMPA receptor regulatory proteins (TARPs). In addition to their function in trafficking, TARPs alter the biophysical properties of AMPA receptors in remarkable ways and thus contribute significantly to the functional plasticity of the synapse. The study of TARP-mediated functional plasticity of AMPA receptors, which has emerged only recently as a hot new field, promises to yield valuable insight into the regulation of neuronal communication. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available