Journal
NEUROREPORT
Volume 24, Issue 6, Pages 324-328Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32835fc827
Keywords
acetazolamide; aquaporin; regional cerebral blood flow; TGN-020
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (Japan)
- University of Niigata
- Grants-in-Aid for Scientific Research [25461310] Funding Source: KAKEN
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The effects of the aquaporin-4 (AQP-4) inhibitor TGN-020 on regional cerebral blood flow (rCBF) was examined in wild-type (WT) and AQP-4 knockout (KO) mice in vivo. Although baseline absolute rCBF of WT and KO mice were equivalent (158.9 +/- 17.7 and 155.5 +/- 10.4 ml/100 g/min, respectively), TGN-020 produced a significant increase in rCBF compared with saline-treated WT mice (control), reaching a plateau 20 min after administration (118.45 +/- 8.13%, P<0.01). TGN-020 showed no effect on KO mice, supporting the concept that the observed increase in rCBF in WT mice was AQP-4 dependent. Administration of acetazolamide (positive control) produced an even greater increase in rCBF in WT compared with TGN-020 and a similar response in KO mice as well, reaching a sustained plateau 5 min after administration (138.50 +/- 9.75 and 138.52 +/- 9.76%, respectively, P<0.01 compared with baseline or saline-treated control mice). The study demonstrated that AQP-4 plays a role in regulation of rCBF. NeuroReport 24:324-328 (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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