Journal
NEUROREPORT
Volume 23, Issue 2, Pages 113-118Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32834ebf44
Keywords
auditory-evoked field; auditory hypersensitivity; autistic spectrum disorder; magnetoencephalography
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [23591494]
- Grants-in-Aid for Scientific Research [24000012, 22591126, 23590672, 23390347, 23591494] Funding Source: KAKEN
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The aim of this study was to investigate the differential responses of the primary auditory cortex to auditory stimuli in autistic spectrum disorder with or without auditory hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine with and nine without auditory hypersensitivity) with autistic spectrum disorder and 12 age-matched controls. Autistic disorder with hypersensitivity showed significantly more delayed M50/M100 peak latencies than autistic disorder without hypersensitivity or the control. M50 dipole moments in the hypersensitivity group were statistically larger than those in the other two groups. M50/M100 peak latencies were correlated with the severity of auditory hypersensitivity; furthermore, severe hypersensitivity induced more behavioral problems. This study indicates auditory hypersensitivity in autistic spectrum disorder as a characteristic response of the primary auditory cortex, possibly resulting from neurological immaturity or functional abnormalities in it. NeuroReport 23:113-118 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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