Journal
NEUROREPORT
Volume 22, Issue 8, Pages 407-411Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328346e16e
Keywords
caudate; [C-11]raclopride; dopamine D2 receptor; internet addiction; PET; putamen; striatum
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Funding
- Korean Government (MOEHRD) [KRF-2008-532- E00018]
- Brain Research Center [2010K000817]
- Ministry of Education, Science and Technology of Republic of Korea [20100029261, 2009-0083265]
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An increasing amount of research has suggested that Internet addiction is associated with abnormalities in the dopaminergic brain system. We hypothesized that Internet addiction would be associated with reduced levels of dopaminergic receptor availability in the striatum compared with controls. To test this hypothesis, a radiolabeled ligand [C-11]raclopride and positron emission tomography was used to assess dopamine D2 receptor binding potential in men with and without Internet addiction. Consistent with our prediction, individuals with Internet addiction showed reduced levels of dopamine D2 receptor availability in subdivisions of the striatum including the bilateral dorsal caudate and right putamen. This finding contributes to the understanding of neurobiological mechanism of Internet addiction. NeuroReport 22:407-411 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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