Journal
NEUROREPORT
Volume 22, Issue 12, Pages 575-580Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328348e6aa
Keywords
conditioned place preference; heroin; histone H3 phosphoacetylation
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Funding
- Ministry of Science and Technology [2009CB522000]
- National Natural Science Foundation of China [30901798, 30701019]
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We investigated the role of histone H3 phosphoacetylation in the nucleus accumbens (NAc) in heroin-conditioned place preference paradigm. Heroin could dose-dependently increase histone H3 phosphoacetylation specifically in the NAc and could enhance heroin place preference. Injection of trichostatin A into the NAc significantly augmented heroin-induced histone H3 phosphoacetylation and enhanced heroin place preference. Conversely, injection of MK-801 into the NAc attenuated histone H3 phosphoacetylation and reduced heroin place preference. These data suggest that histone H3 phosphoacetylation in the NAc may play a critical role in heroin addiction. NeuroReport 22:575-580 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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