Journal
NEUROREPORT
Volume 22, Issue 8, Pages 391-395Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328346bf85
Keywords
Alzheimer's disease; atrophy; brain structure; folate; homocysteine; magnetic resonance imaging; vitamin B
Categories
Funding
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- National Institute on Aging [R01 AG020098]
- National Institute of Biomedical Imaging and Bioengineering [R01 EB008281]
- NIH [P30 AG010129, K01 AG030514]
- Dana Foundation
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Elevated homocysteine levels are a known risk factor for Alzheimer's disease and vascular disorders. Here we applied tensor-based morphometry to brain magnetic resonance imaging scans of 732 elderly individuals from the Alzheimer's Disease Neuroimaging Initiative study, to determine associations between homocysteine and brain atrophy. Those with higher homocysteine levels showed greater frontal, parietal, and occipital white matter atrophy in the entire cohort, irrespective of diagnosis, age, or sex. This association was also found when considering mild cognitive impairment individuals separately. Vitamin B supplements, such as folate, may help prevent homocysteine-related atrophy in Alzheimer's disease by possibly reducing homocysteine levels. These atrophy profiles may, in the future, offer a potential biomarker to gauge the efficacy of interventions using dietary folate supplementation. NeuroReport 22:391-395 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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