Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice

Nesfatin-1 was recently identified as a peptide with anorexigenic effects that is localized in the hypothalamus and adipocytes. Not much is known about the effect of nesfatin-1 on gut motility. Food intake was measured after intracerebroventricular administration of nesfatin-1 in food-deprived mice. Antral and duodenal motility was assessed by using a manometric method in conscious fed mice. We found that centrally administered nesfatin-1 decreased food intake and inhibited gastroduodenal motility in mice. These results suggest that nesfatin-1 influences gut motility and feeding behaviour. NeuroReport 21:1008-1011 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.