Journal
NEUROREPORT
Volume 21, Issue 1, Pages 39-44Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32833312fe
Keywords
anaphase-promoting complex; Cdh1; cell differentiation; stem cells
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Funding
- National Natural Science Foundation of China [30571788]
- China Scholarship Council [2008616039]
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The anaphase-promoting complex (APC) is a multisubunit E3 ubiquitin ligase that controls cell cycle transition in proliferating cells. Recent studies show that Cdh1-APC is active in postmitotic neurons, which regulates axonal growth and patterning, synaptic development and neuronal survival. However, the role of Cdh1-APC in neural stem cells differentiation remains unknown. Using quantitative reverse transcription-PCR, we observed that Cdh1 was expressed higher in neurons than in neural stem cells in vitro. Cdh1 was upregulated, whereas Id2 (one downstream substrate of Cdh1-APC) was downregulated when primary neural stem cells were induced to differentiate into neurons by all-trans retinoic acid. This observation suggests that Cdh1 is involved in the control of neural stem cells differentiated into neurons. NeuroReport 21:39-44 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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