Journal
NEUROREPORT
Volume 20, Issue 18, Pages 1634-1637Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32833370cf
Keywords
adenosine; anoxia; hippocampus; hypoxia; paired-pulse facilitation; synaptic transmission
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Funding
- National Institutes of Health [DC005793]
- National Science Foundation [0744979]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0744979] Funding Source: National Science Foundation
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Mammalian brains have extremely high levels of aerobic metabolism and typically suffer irreversible damage after brief periods of oxygen deprivation such as occur during stroke or cardiac arrest Here we report that brain tissue from naked mole-rats, rodents that live in a chronically low-oxygen environment is remarkably resistant to hypoxia: naked mole-rat neurons maintain synaptic transmission much longer than mouse neurons and can recover from periods of anoxia exceeding 30 min. We suggest that brain tolerance to hypoxia may result from slowed or arrested brain development in these extremely long-lived animals. NeuroReport 20:1634-1637 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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