Journal
NEUROREPORT
Volume 20, Issue 12, Pages 1098-1103Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32832e34ee
Keywords
CCL2; Huntington's disease; IL-6; IL-8; IL-10; microglia; MMP9; neuroinflammation
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Funding
- CHDI Foundation, New York
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Neuroinflammation is a prominent feature of many neurodegenerative diseases, however, little is known about neuroinflammation in Huntington's disease. We used quantitative real time-PCR to compare the expression level of neuroinflammation-associated mediators in the striatum, cortex, and cerebellum from post-mortem Huntington's disease patient samples with controls. We found increased expression of several key inflammatory mediators, including CCL2 and IL-10, specifically in the striatum of Huntington's disease patients, the main area affected by this pathology. Remarkably, we also found upregulation of IL-6, IL-8, and MMP9, in the cortex and notably the cerebellum, a brain area commonly thought to be spared by Huntington's disease. Our data suggest that neuroinflammation is a prominent feature associated with Huntington's disease and may constitute a novel target for therapeutic intervention. NeuroReport 20:1098-1103(C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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