Journal
NEUROREPORT
Volume 20, Issue 6, Pages 553-557Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3283293e59
Keywords
dentate gyrus; glucocorticoid; hippocampus; hypothalamo-pituitary-adrenal axis; neurogenesis; stress
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Funding
- National Institutes of Health
- National Institute of Mental Health (Bethesda, Maryland, USA)
- National Institute of Mental Health
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Stress and glucocorticoids are among the strongest inhibitors of adult hippocampal neurogenesis. Despite the known role of the hippocampus in negative feedback regulation of the hypothalamo-pituitary-adrenal axis, whether the loss of hippocampal neurogenesis affects this inhibition has not been examined. Here we tested whether suppression of adult neurogenesis affected the hypothalamo-pituitary-adrenal axis response. Our results show that suppression of neurogenesis leads to a potentiated hypothalamo-pituitary-adrenal axis response after an exposure to a mild stressor. This study suggests that suppressed neurogenesis regulates the hypothalamo-pituitary-adrenal axis response. NeuroReport 20:553-557 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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