Journal
NEUROREPORT
Volume 20, Issue 7, Pages 663-668Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32832a09f8
Keywords
cytokines; dorsal root ganglion; gp130; regeneration; Schwann cells; signal transducer and activator of transcription 3
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Funding
- Korea Science and Engineering Foundation [R01-2008-000-10213-0]
- National Research Foundation of Korea [R01-2008-000-10213-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Nerve injury-induced activation of signal transducer and activator of transcription 3 (STAT3) in sensory neurons and Schwann cells has been implicated in peripheral nerve regeneration. In this study, we investigated the role of gp130-related cytokines including interleukin-6 (IL-6), ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF) in STAT3 activation in dorsal root ganglion neurons, Schwann cells, and endoneurial fibroblasts. We found that IL-6, but not CNTF or LIF, activated STAT3 in Schwann cells. However, CNTF and LIF, but not IL-6, activated STAT3 in dorsal root ganglion neurons. Furthermore, LIF was the primary activator of STAT3 in endoneurial fibroblasts. These findings indicate that gp130 cytokines may have cell type-specific roles in peripheral nerve regeneration. NeuroReport 20:663-668 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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