Journal
NEUROREPORT
Volume 20, Issue 11, Pages 984-989Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32832d0a67
Keywords
anxiety; functional magnetic resonance imaging; mentalizing; social cognition; trust
Categories
Funding
- National Institute of Mental Health (NIMH) [MH076198]
- Brain Research Foundation
- NIMH Mental Health Research Education [R25MH063742]
- University of Chicago, Chicago, Illinois, USA
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Individuals with generalized social anxiety disorder tend to make overly negative and distorted predictions about social events, which enhance perceptions of threat and contribute to excessive anxiety in social situations. Here, we coupled functional magnetic resonance imaging and a multiround economic exchange game ('trust game') to probe mentalizing, the social-cognitive ability to attribute mental states to others. Relative to interactions with a computer, those with human partners ('mentalizing') elicited less activation of medial prefrontal cortex in generalized social anxiety patients compared with matched healthy control participants. Diminished medial prefrontal cortex function may play a role in the social-cognitive pathophysiology of social anxiety. NeuroReport 20:984-989 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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