Journal
NEUROREPORT
Volume 20, Issue 1, Pages 69-73Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328315cd35
Keywords
dopamine; hypothalamic-hypophyseal-pituitary axis; manganese; pituitary-specific transacting factor 1; prolactin
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Funding
- Inje University
- The Occupational Safety and Health Research Institute
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Although manganese (Mn) has been shown to increase prolactin (PRL) by decreasing dopamine (DA) in the hypothalamus, the mechanism of Mn-induced regulation of the hypothalamic-hypophyseal-pituitary axis is unclear. We assessed the effects of inhaled Mn on hypothalamic DA and pituitary PRL production and evaluated the role of pituitary-specific transacting factor 1 (Pit-1), a transacting factor of PRL gene, in Mn-induced changes in PRL secretion in the rat brain. Male rats exposed to Mn for 4 or 13 weeks (1.5 mg/m(3), 6 h/day, 5 days/week) showed a progressive and significant decrease in hypothalamic DA, whereas PRL and Pit-1 mRNA levels increased in response to Mn exposure. These results suggest that exposure to Mn decreases hypothalamic DA and promotes the production of PRL in the pituitary and that Pit-1 might be a regulator of DA and PRL. NeuroReport 20:69-73 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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