Journal
NEUROREPORT
Volume 20, Issue 10, Pages 946-950Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32832c7e50
Keywords
amacrine cell; ganglion cell; immunofluorescence double labeling; inner retina; TASK-2
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Funding
- Ministry of Science and Technology of China [2006CB500800, 2007CB512200]
- Natural Science Foundation of China [90408003, 30570593, 30770698]
- Ministry of Education of China
- Innovative Research Team in University (PCSIRT)
- Shanghai Pujiang Program
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TASK-2 is a member of tandem-pore domain potassium channels that regulate neuronal excitability. In this study we investigated the expression of TASK-2 in neuronal elements in the inner retina of rat by immunofluorescence double labeling. In contrast to weak expression in the outer retina, TASK-2 is strongly expressed in the inner retina. TASK-2 immunoreactivity was diffusely distributed throughout the inner plexiform layer. Double-labeling experiments revealed that TASK-2 was expressed in gamma-aminobutyric acid amacrine cells (GABAergic amacrine cells), including both dopaminergic and cholinergic ones. The immunostaining appeared on the membrane, cytoplasm, and somatodendritic compartments of these cells. In All glycinergic amacrine cells, however, only faint punctuate staining, if any, was seen. In addition, ganglion cells were also intensely labeled by TASK-2. NeuroReport 20:946-950 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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