Journal
NEUROREPORT
Volume 20, Issue 1, Pages 9-12Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32831b9ce4
Keywords
cocaine; conditioned place preference; dopamine transporter; knockin mice
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Funding
- NIDA NIH HHS [R01 DA020124, DA 014610, R01 DA014610] Funding Source: Medline
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We have previously reported that knockin mice with a cocaine-insensitive dopamine transporter (DAT-CI mice) do not experience cocaine reward, as measured by conditioned place preference. This conclusion has come under scrutiny because some genetically modified mice show cocaine-induced conditioned place preference in a narrow dose range, that is, responding at doses around 10 mg/kg, but not at 5 and 20 mg/kg, the doses we tested in DAT-CI mice. These results raise the possibility that we have missed the optimal dose for cocaine response. Here we report that cocaine does not produce reward in DAT-CI mice at low, moderate, and high doses, including 10 mg/kg. This study strengthens our conclusion that DAT inhibition is required for cocaine reward in mice with a functional dopaminergic system. NeuroReport 20:9-12 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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