Journal
NEUROREPORT
Volume 20, Issue 2, Pages 150-156Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32831c50df
Keywords
Alpha synuclein; ATP13A2; autophagy impairment; DJ-1; leucine-rich repeat kinase 2; mitochondrial dysfunction; parkin; PTEN-induced kinase 1; ubiquitin-dependent proteasomal dysfunction
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Funding
- Parkinson's UK [G-4051, G-4065] Funding Source: Medline
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Parkinson's disease is the second most common neurodegenerative disorder and remains incurable. Considerable progress has been made in understanding the molecular mechanisms of this disease, in particular, a distinct set of genes have emerged, whose dysfunctional regulation is strongly associated with the condition. These genes include alpha-synuclein, parkin, PTEN induced Putative Kinase 1 (PINK1), DJ-1, Leucine Rich Repeat Kinase 2 (LRRK2) and ATP13A2. Here we discuss what has been learnt in the study of these genes and how these genes may contribute to the pathogenesis of Parkinson's disease through different molecular pathways, and consider how these pathways might converge to lead to the onset of Parkinson's disease. NeuroReport 20:150-156 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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