Journal
NEUROREPORT
Volume 19, Issue 17, Pages 1705-1708Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3283174415
Keywords
corticospinal tract; diffusion tensor imaging; fractional anisotropy; superior longitudinal fasciculus
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Funding
- NCRR NIH HHS [P41 RR013642, U54 RR021813, P41 RR13642, P41 RR013642-11, U54 RR021813-045955] Funding Source: Medline
- NIMH NIH HHS [K01 MH073990, P50 MH073466-01] Funding Source: Medline
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We used diffusion tensor imaging to investigate fractional anisotropy (FA), a measure of fiber tract integrity, in attention-deficit hyperactivity disorder (ADHD). Using a tract-based atlasing approach on six-direction diffusion tensor imaging data, we examined FA within the cingulum, corpus callosum, corticospinal tract, fornix, optic radiations, superior longitudinal fasciculus, uncinate fasciculus, and the superior and inferior occipitofrontal fasciculi in an all-male sample of 17 children and adolescents with ADHD and 16 age-matched controls. ADHD patients had significantly lower FA in the corticospinal tract (P=0.02) and the superior longitudinal fasciculus (P=0.017) compared with controls. Results support that disruptions in motor and attentional networks may contribute toward ADHD pathophysiology. Future research may clarify how ADHD subtype and psychiatric comorbidities affect diffusion measures. NeuroReport 19:1705-1708 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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