Journal
NEUROREPORT
Volume 19, Issue 7, Pages 703-709Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3282fb8203
Keywords
commissurotomy; diffusion tensor imaging; interhemispheric interaction; laterality; resting-state functional connectivity
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Funding
- NIMH NIH HHS [5R21MH066393, 5T32MH067763, T32 MH067763, R21 MH066393] Funding Source: Medline
- NINDS NIH HHS [NS20187, R01 NS020187] Funding Source: Medline
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Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.
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