Journal
NEUROREPORT
Volume 19, Issue 11, Pages 1159-1162Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32830867c4
Keywords
aging; cognitive abilities; fast spindles; slow spindles; stage 2 sleep
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Funding
- Austrian Science Fund FWF [J 2470] Funding Source: Medline
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Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD patients. Postlearning sleep was recorded. Sleep spindles were globally reduced in aging and AD. AD patients also exhibited a further decrease in fast spindles. Besides, mean intensity of fast spindles was positively correlated, in AD patients, with immediate recall performance. Our results are the first report of a specific decrease in fast spindles in AD, associated with learning abilities. They also give further hints for a functional differentiation between slow and fast spindles. NeuroReport 19:1159-1162 (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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