Journal
NEUROREPORT
Volume 19, Issue 1, Pages 59-62Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3282f2e2d1
Keywords
deep brain stimulation; idiopathic Parkinson's disease; local field potential recordings; pedunculopontine nucleus
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Funding
- MRC [G0400617] Funding Source: UKRI
- Medical Research Council [G0400617] Funding Source: researchfish
- Medical Research Council [G0400617] Funding Source: Medline
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The pedunculopontine nucleus has recently been introduced as a new therapeutic target for deep brain stimulation in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus. Therefore, we looked for and demonstrated evidence of low frequency synchronization of activity in the pedunculopontine nucleus of a patient with Parkinson's disease that increased after treatment with dopamine and which might be mimicked by local deep brain stimulation at low frequency.
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