Journal
NEUROREPORT
Volume 19, Issue 7, Pages 751-755Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3282fda231
Keywords
addiction; cocaine; conditioning place preference; globus pallidus; neurexins; neuroligins; substantia nigra; subthalamic nucleus
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Dysfunctions affecting the connections of basal ganglia lead to major neurological and psychiatric disorders. We investigated levels of mRNA for three neurexins (Nrxn) and three neuroligins (Nlgn) in the globus pallidus, subthalamic nucleus, and substantia nigra, in control conditions and after short-term exposure to cocaine. The expression of Nrxn2 beta and Nlgn3 in the substantia nigra and Nlgnl in the subthalamic nucleus depended on genetic background. The development of short-term cocaine appetence induced an increase in Nrxn3 beta expression in the globus pallidus. Human NRXN3 has recently been linked to several addictions. Thus, NRXN3 adhesion molecules may play an important role in the synaptic plasticity of neurons involved in the indirect pathways of basal ganglia, in which they regulate reward-related learning.
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