Journal
NEUROPSYCHOPHARMACOLOGY
Volume 40, Issue 1, Pages 113-128Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2014.230
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Funding
- Intramural Program of the National Institute of Mental Health, National Institutes of Health, USA [1ZIAMH002784]
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002784] Funding Source: NIH RePORTER
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Several lines of evidence suggest that adult neurogenesis, the production of new neurons in adulthood, may play a role in psychiatric disorders, including depression, anxiety, and schizophrenia. Medications and other treatments for mental disorders often promote the proliferation of new neurons; the time course for maturation and integration of new neurons in circuitry parallels the delayed efficacy of psychiatric therapies; adverse and beneficial experiences similarly affect development of mental illness and neurogenesis; and ablation of new neurons in adulthood alters the behavioral impact of drugs in animal models. At present, the links between adult neurogenesis and depression seem stronger than those suggesting a relationship between new neurons and anxiety or schizophrenia. Yet, even in the case of depression there is currently no direct evidence for a causative role. This article reviews the data relating adult neurogenesis to mental illness and discusses where research needs to head in the future.
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